<address id="lxrbh"></address>
      <em id="lxrbh"><span id="lxrbh"></span></em>

      ScienceDaily
      Your source for the latest research news
      Follow Facebook Twitter LinkedIn Subscribe RSS Feeds Newsletters
      New:
      • New Physics and the Early Universe
      • How SARS-CoV-2 Rapidly Damages Human Lung Cells
      • Greenland Ice Sheet Faces Irreversible Melting
      • Early Changes in Alzheimer’s Before Symptoms
      • Fingerprints Strengthen Human Touch
      • Is It Better to Give Than Receive?
      • New Hubble Data Explains Missing Dark Matter
      • What Triggers Leaf Die-Off in Autumn?
      • Alligators Can Regrow Their Tails Too
      • Two Liquid States of Water Exist
      advertisement
      Follow all of ScienceDaily's latest research news and top science headlines!
      Science News
      from research organizations

      1

      2

      Previous infection with other types of coronaviruses may lessen severity of COVID-19

      Date:
      October 6, 2020
      Source:
      Boston Medical Center
      Summary:
      Being previously infected with a coronaviruses that cause the 'common cold' may decrease the severity of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infections, according to a new study.
      Share:
      FULL STORY

      Person blowing nose | Credit: © Alliance / stock.adobe.com
      Person blowing nose (stock image).
      Credit: © Alliance / stock.adobe.com
      Person blowing nose | Credit: © Alliance / stock.adobe.com
      Person blowing nose (stock image).
      Credit: © Alliance / stock.adobe.com

      Being previously infected with a coronaviruses that cause the "common cold" may decrease the severity of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infections, according to results of a new study. Led by researchers at Boston Medical Center and Boston University School of Medicine, the study also demonstrates that the immunity built up from previous non-SARS-CoV-2 coronavirus infections does not prevent individuals from getting COVID-19. Published in the Journal of Clinical Investigation, the findings provide important insight into the immune response against SARS-CoV-2, which could have significant implications on COVID-19 vaccine development.

      advertisement

      The COVID-19 pandemic has led to more than 200,000 deaths in the US, and more than one million globally. There is a growing body of research looking into specific ways that the SARS-CoV-2 virus impacts different populations, including why some people are infected and are asymptomatic, as well as what increases ones mortality as a result of infection. There are a number of vaccines under development in order to determine what type of vaccine (mRNA, viral vector) will be most effective at preventing SARS-CoV-2 infections.

      While SARS-CoV-2 is a relatively new pathogen, there are many other types of coronaviruses that are endemic in humans and can cause the "common cold" and pneumonia. These coronaviruses share some genetic sequences with SARS-CoV-2, and the immune responses from these coronaviruses can cross-react against SARS-CoV-2.

      In this study, the researchers looked at electronic medical record data from individuals who had a respiratory panel test (CRP-PCR) result between May 18, 2015 and March 11, 2020. The CRP-PCR detects diverse respiratory pathogens including the endemic "common cold" coronaviruses. They also examined data from individuals who were tested for SARS-CoV-2 between March 12, 2020 and June 12, 2020. After adjusting for age, gender, body mass index, and diabetes mellitus diagnosis, COVID-19 hospitalized patients who had a previous positive CRP-PCR test result for a coronoavirus had significantly lower odds of being admitted to the intensive care unit (ICU), and lower trending odds of requiring mechanical ventilation during COVID. The probability of survival was also significantly higher in COVID-19 hospitalized patients with a previous positive test result for a "common cold" coronoavirus. However, a previous positive test result for a coronavirus did not prevent someone from getting infected with SARS-CoV-2.

      "Our results show that people with evidence of a previous infection from a "common cold" coronavirus have less severe COVID-19 symptoms," said Manish Sagar, MD, an infectious diseases physician and researcher at Boston Medical Center, associate professor of medicine and microbiology at Boston University School of Medicine and the study's co-corresponding author. Another interesting finding, the authors note, is that immunity may prevent disease (COVID-19) in ways that are different from preventing infection by SARS-CoV-2. This is demonstrated by the fact that the patient groups had similar likelihoods of infection but differing likelihoods of ending up in the ICU or dying.

      "People are routinely infected with coronaviruses that are different from SARS-CoV-2, and these study results could help identify patients at lower and greater risk of developing complications after being infected with SARS-CoV-2," said Joseph Mizgerd, ScD, professor of medicine, microbiology, and biochemistry at Boston University School of Medicine who is the study's co-corresponding author. "We hope that this study can be the springboard for identifying the types of immune responses for not necessarily preventing SARS-CoV-2 infection but rather limiting the damage from COVID-19."

      This study was supported in part by grants from the National Institutes of Health (R35 HL-135756 to JPM, K24 AI-145661 to MS, 5T32 AI-052074-13 to PS, and R01 GM-122876 to LFW). Sagar's work is also facilitated by the Providence/Boston Center for AIDS Reearch (P30AI042853).

      make a difference: sponsored opportunity

      Story Source:

      Materials provided by Boston Medical Center. Note: Content may be edited for style and length.


      Journal Reference:

      1. Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura White, Joseph P. Mizgerd. Recent endemic coronavirus infection is associated with less severe COVID-19. Journal of Clinical Investigation, 2020; DOI: 10.1172/JCI143380

      Cite This Page:

      • MLA
      • APA
      • Chicago
      Boston Medical Center. "Previous infection with other types of coronaviruses may lessen severity of COVID-19." ScienceDaily. ScienceDaily, 6 October 2020. <www.theclynefaction.com/releases/2020/10/201006132110.htm>.
      Boston Medical Center. (2020, October 6). Previous infection with other types of coronaviruses may lessen severity of COVID-19. ScienceDaily. Retrieved December 3, 2020 from www.theclynefaction.com/releases/2020/10/201006132110.htm
      Boston Medical Center. "Previous infection with other types of coronaviruses may lessen severity of COVID-19." ScienceDaily. www.theclynefaction.com/releases/2020/10/201006132110.htm (accessed December 3, 2020).

      • RELATED TOPICS
        • Health & Medicine
          • Infectious Diseases
          • Cold and Flu
          • Vaccines
          • Diseases and Conditions
          • HIV and AIDS
          • Immune System
          • Today's Healthcare
          • Personalized Medicine
      advertisement

      • RELATED TERMS
        • Severe acute respiratory syndrome
        • Upper respiratory tract infection
        • Common cold
        • Virus
        • Yellow fever
        • Obstructive sleep apnea
        • Delirium
        • Anthrax

      1

      2

      3

      4

      5
      RELATED STORIES

      Coronaviruses Do Not Readily Induce Cross-Protective Antibody Responses
      May 18, 2020 — Patients infected with either severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 produce antibodies that bind to the other coronavirus, but the cross-reactive antibodies are not ...
      New Coronavirus Emerges from Bats in China, Devastates Young Swine
      Apr. 4, 2018 — A newly identified coronavirus that killed nearly 25,000 piglets in 2016-17 in China emerged from horseshoe bats near the origin of the severe acute respiratory syndrome coronavirus (SARS-CoV), which ...
      Broad Spectrum Antiviral Drug Inhibits a Range of Emerging Coronaviruses
      Mar. 6, 2018 — Researchers have long known that RNA viruses called coronaviruses cause the common cold and pneumonia. In the last two decades or so, though, researchers have found that these viruses can jump ...
      Bats Are the Major Reservoir of Coronaviruses Worldwide
      June 12, 2017 — Results of a five-year study in 20 countries on three continents have found that bats harbor a large diversity of coronaviruses (CoV), the family of viruses that cause severe acute respiratory ...
      FROM AROUND THE WEB

      ScienceDaily shares links with sites in the TrendMD network and earns revenue from third-party advertisers, where indicated.
        Print   Email   Share

      advertisement

      1

      2

      3

      4

      5
      Most Popular
      this week

      HEALTH & MEDICINE
      The Six Strains of SARS-CoV-2
      Glucosamine May Reduce Overall Death Rates as Effectively as Regular Exercise, Study Suggests
      (c) (c) Photocreo Bednarek / AdobeResearchers Examine Which Approaches Are Most Effective at Reducing COVID-19 Spread
      MIND & BRAIN
      (c) (c) pelooyen / AdobeZebra Finches Amazing at Unmasking the Bird Behind the Song
      (c) (c) whitehoune / AdobeFrom the Inside Out: How the Brain Forms Sensory Memories
      (c) (c) oatawa / AdobeHealthy Sleep Habits Help Lower Risk of Heart Failure
      LIVING & WELL
      Boy or Girl? It's in the Father's Genes
      Aim to Exceed Weekly Recommended Physical Activity Level to Offset Health Harms of Prolonged Sitting
      Everyday Activities Enhance Personal Well-Being
      advertisement

      Strange & Offbeat
       

      HEALTH & MEDICINE
      Biofriendly Protocells Pump Up Blood Vessels
      Researchers Identify Features That Could Make Someone a Virus Super-Spreader
      New Effective and Safe Antifungal Isolated from Sea Squirt Microbiome
      MIND & BRAIN
      (c) (c) pelooyen / AdobeZebra Finches Amazing at Unmasking the Bird Behind the Song
      A Malformation Illustrates the Incredible Plasticity of the Brain
      Water Fleas on 'Happy Pills' Have More Offspring
      LIVING & WELL
      Key Advance for Printing Circuitry on Wearable Fabrics
      Luminescent Wood Could Light Up Homes of the Future
      Research Lays Groundwork for Ultra-Thin, Energy Efficient Photodetector on Glass
      SD
      • SD
        • Home Page
        • Top Science News
        • Latest News
      • Home
        • Home Page
        • Top Science News
        • Latest News
      • Health
        • View all the latest top news in the health sciences,
          or browse the topics below:
          Health & Medicine
          • Allergy
          • Alternative Medicine
          • Birth Control
          • Cancer
          • Diabetes
          • Diseases
          • Heart Disease
          • HIV and AIDS
          • Obesity
          • Stem Cells
          • ... more topics
          Mind & Brain
          • ADD and ADHD
          • Addiction
          • Alzheimer's
          • Autism
          • Depression
          • Headaches
          • Intelligence
          • Psychology
          • Relationships
          • Schizophrenia
          • ... more topics
          Living Well
          • Parenting
          • Pregnancy
          • Sexual Health
          • Skin Care
          • Men's Health
          • Women's Health
          • Nutrition
          • Diet and Weight Loss
          • Fitness
          • Healthy Aging
          • ... more topics
      • Tech
        • View all the latest top news in the physical sciences & technology,
          or browse the topics below:
          Matter & Energy
          • Aviation
          • Chemistry
          • Electronics
          • Fossil Fuels
          • Nanotechnology
          • Physics
          • Quantum Physics
          • Solar Energy
          • Technology
          • Wind Energy
          • ... more topics
          Space & Time
          • Astronomy
          • Black Holes
          • Dark Matter
          • Extrasolar Planets
          • Mars
          • Moon
          • Solar System
          • Space Telescopes
          • Stars
          • Sun
          • ... more topics
          Computers & Math
          • Artificial Intelligence
          • Communications
          • Computer Science
          • Hacking
          • Mathematics
          • Quantum Computers
          • Robotics
          • Software
          • Video Games
          • Virtual Reality
          • ... more topics
      • Enviro
        • View all the latest top news in the environmental sciences,
          or browse the topics below:
          Plants & Animals
          • Agriculture and Food
          • Animals
          • Biology
          • Biotechnology
          • Endangered Animals
          • Extinction
          • Genetically Modified
          • Microbes and More
          • New Species
          • Zoology
          • ... more topics
          Earth & Climate
          • Climate
          • Earthquakes
          • Environment
          • Geography
          • Geology
          • Global Warming
          • Hurricanes
          • Ozone Holes
          • Pollution
          • Weather
          • ... more topics
          Fossils & Ruins
          • Ancient Civilizations
          • Anthropology
          • Archaeology
          • Dinosaurs
          • Early Humans
          • Early Mammals
          • Evolution
          • Lost Treasures
          • Origin of Life
          • Paleontology
          • ... more topics
      • Society
        • View all the latest top news in the social sciences & education,
          or browse the topics below:
          Science & Society
          • Arts & Culture
          • Consumerism
          • Economics
          • Political Science
          • Privacy Issues
          • Public Health
          • Racial Disparity
          • Religion
          • Sports
          • World Development
          • ... more topics
          Business & Industry
          • Biotechnology & Bioengineering
          • Computers & Internet
          • Energy & Resources
          • Engineering
          • Medical Technology
          • Pharmaceuticals
          • Transportation
          • ... more topics
          Education & Learning
          • Animal Learning & Intelligence
          • Creativity
          • Educational Psychology
          • Educational Technology
          • Infant & Preschool Learning
          • Learning Disorders
          • STEM Education
          • ... more topics
      • Quirky
        • Top News
        • Human Quirks
        • Odd Creatures
        • Bizarre Things
        • Weird World
      Free Subscriptions

      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      • Email Newsletters
      • RSS Feeds
      Follow Us

      Keep up to date with the latest news from ScienceDaily via social networks:

      • Facebook
      • Twitter
      • LinkedIn
      Have Feedback?

      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?

      • Leave Feedback
      • Contact Us
      About This Site  |  Staff  |  Reviews  |  Contribute  |  Advertise  |  Privacy Policy  |  Editorial Policy  |  Terms of Use
      Copyright 2020 ScienceDaily or by other parties, where indicated. All rights controlled by their respective owners.
      Content on this website is for information only. It is not intended to provide medical or other professional advice.
      Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners.
      Financial support for ScienceDaily comes from advertisements and referral programs, where indicated.
      — CCPA: Do Not Sell My Information — — GDPR: Privacy Settings —
      118论坛 118网址之家