<address id="lxrbh"></address>
      <em id="lxrbh"><span id="lxrbh"></span></em>

      ScienceDaily
      Your source for the latest research news
      Follow Facebook Twitter LinkedIn Subscribe RSS Feeds Newsletters
      New:
      • New Physics and the Early Universe
      • How SARS-CoV-2 Rapidly Damages Human Lung Cells
      • Greenland Ice Sheet Faces Irreversible Melting
      • Early Changes in Alzheimer’s Before Symptoms
      • Fingerprints Strengthen Human Touch
      • Is It Better to Give Than Receive?
      • New Hubble Data Explains Missing Dark Matter
      • What Triggers Leaf Die-Off in Autumn?
      • Alligators Can Regrow Their Tails Too
      • Two Liquid States of Water Exist
      advertisement
      Follow all of ScienceDaily's latest research news and top science headlines!
      Science News
      from research organizations

      1

      2

      Tracer molecule may improve imaging tests for brain injury

      Agent shows promising results in nonhuman primates

      Date:
      October 22, 2020
      Source:
      Massachusetts General Hospital
      Summary:
      Researchers have validated a new radiolabeled molecule that can be used with imaging tests to accurately detect and characterize brain injury.
      Share:
      FULL STORY

      Researchers have validated a new radiolabeled molecule that can be used with imaging tests to accurately detect and characterize brain injury. The team, led by investigators at Massachusetts General Hospital (MGH), recently received clearance from the U.S. Food and Drug Administration (FDA) to initiate a first-in-human study with the strategy.

      advertisement

      As described in the Journal of Cerebral Blood Flow & Metabolism, the novel tracer, called [18F]3F4AP, is designed to bind to potassium channels and is radiolabeled so it can be visualized through positron emission tomography (PET) imaging. Potassium channels in the brain's neurons become exposed when the neurons become demyelinated, or lose their protective coating (called myelin), which occurs with a variety of neurodegenerative conditions.

      "Because potassium channels increase in expression and accessibility upon demyelination, this tracer holds promise for imaging multiple sclerosis and other diseases such as traumatic brain and spinal cord injuries, stroke and Alzheimer's disease," said co-senior author Pedro Brugarolas, PhD, an investigator in MGH's Gordon Center for Medical Imaging and an assistant professor in the Department of Radiology at Harvard Medical School.

      When tested in monkeys, [18F]3F4AP exhibited excellent properties for brain imaging, including high penetration into the brain, fast washout or clearance, and excellent reproducibility when tested multiple times, researchers say. Furthermore, "the tracer showed unusually high resistance to metabolic degradation and minimal binding to blood proteins -- properties that are difficult to come by and are highly beneficial in PET imaging," said lead author Nicolas Guehl, PhD, an investigator in the Department of Radiology at MGH and an instructor in radiology at Harvard Medical School (HMS).

      Also, the tracer generated a high signal in the right frontal cortex of a monkey that the researchers later learned had sustained a minor brain injury several years before being transferred to them. "The tracer detected the brain lesion better than other PET tracers commonly used for brain imaging and better than magnetic resonance imaging, the standard imaging modality used to detect demyelination," said co-senior author Marc Normandin, PhD, assistant director of MGH's Gordon Center for Medical Imaging and assistant professor at HMS.

      The team is now poised to test the work in patients with clearance from the FDA. "There are many tracers developed and tested in animals that never make it to humans, so this is an important achievement," said Daniel Yokell, PharmD, associate director for Radiopharmacy and Regulatory Affairs at the Gordon PET Core at MGH, who prepared the FDA Investigational New Drug application that was authorized.

      Testing in humans will likely begin imminently. "We are thrilled to have the MGH Gordon PET Core be the first site to produce [18F]3F4AP for clinical investigations and explore its role in many promising applications," said co-author Georges El Fakhri, PhD, director of MGH's Gordon Center for Medical Imaging and the Nathaniel and Diana Alpert Professor of Radiology at HMS.

      make a difference: sponsored opportunity

      Story Source:

      Materials provided by Massachusetts General Hospital. Note: Content may be edited for style and length.


      Journal Reference:

      1. Nicolas J Guehl, Karla M Ramos-Torres, Clas Linnman, Sung-Hyun Moon, Maeva Dhaynaut, Moses Q Wilks, Paul K Han, Chao Ma, Ramesh Neelamegam, Yu-Peng Zhou, Brian Popko, John A Correia, Daniel S Reich, Georges El Fakhri, Peter Herscovitch, Marc D Normandin, Pedro Brugarolas. Evaluation of the potassium channel tracer [8F]3F4AP in rhesus macaques. Journal of Cerebral Blood Flow & Metabolism, 2020; 0271678X2096340 DOI: 10.1177/0271678X20963404

      Cite This Page:

      • MLA
      • APA
      • Chicago
      Massachusetts General Hospital. "Tracer molecule may improve imaging tests for brain injury: Agent shows promising results in nonhuman primates." ScienceDaily. ScienceDaily, 22 October 2020. <www.theclynefaction.com/releases/2020/10/201022125529.htm>.
      Massachusetts General Hospital. (2020, October 22). Tracer molecule may improve imaging tests for brain injury: Agent shows promising results in nonhuman primates. ScienceDaily. Retrieved December 3, 2020 from www.theclynefaction.com/releases/2020/10/201022125529.htm
      Massachusetts General Hospital. "Tracer molecule may improve imaging tests for brain injury: Agent shows promising results in nonhuman primates." ScienceDaily. www.theclynefaction.com/releases/2020/10/201022125529.htm (accessed December 3, 2020).

      • RELATED TOPICS
        • Mind & Brain
          • Brain Injury
          • Disorders and Syndromes
          • Neuroscience
          • Brain-Computer Interfaces
          • Intelligence
          • Psychology
          • Stroke
          • Multiple Sclerosis
      advertisement

      • RELATED TERMS
        • Brain damage
        • Traumatic brain injury
        • Magnetic resonance imaging
        • Head injury
        • Intellectual giftedness
        • Functional neuroimaging
        • Headache
        • Intelligence quotient

      1

      2

      3

      4

      5
      RELATED STORIES

      Simple 'Sniff Test' Reliably Predicts Recovery of Severely Brain Injured Patients
      Apr. 29, 2020 — The ability to detect smells predicts recovery and long-term survival in patients who have suffered severe brain injury, a new study has found. A simple, inexpensive 'sniff test' could help doctors ...
      Blood Test Method May Predict Alzheimer's Protein Deposits in Brain
      Mar. 2, 2020 — Researchers report an advance in the development of a blood test that could help detect pathological Alzheimer's disease in people who are showing signs of dementia. This approach could be less ...
      Validating Toolbox to Evaluate Cognitive Processing in People With Intellectual Disability
      Feb. 24, 2020 — Researchers have updated and validated a series of tests in the NIH Toolbox Cognitive Battery. These tests, delivered on an iPad, can now be used to accurately assess cognitive processing in people ...
      Single Dose Protects Cognitive Function After Mild Traumatic Brain Injury
      July 11, 2016 — A new molecule could protect the brain from cognitive impairments after a mild traumatic brain injury, according to scientists. Mild traumatic brain injury, or mTBI, is especially common in children, ...
      FROM AROUND THE WEB

      ScienceDaily shares links with sites in the TrendMD network and earns revenue from third-party advertisers, where indicated.
        Print   Email   Share

      advertisement

      1

      2

      3

      4

      5
      Most Popular
      this week

      HEALTH & MEDICINE
      The Six Strains of SARS-CoV-2
      Glucosamine May Reduce Overall Death Rates as Effectively as Regular Exercise, Study Suggests
      (c) (c) Photocreo Bednarek / AdobeResearchers Examine Which Approaches Are Most Effective at Reducing COVID-19 Spread
      MIND & BRAIN
      (c) (c) pelooyen / AdobeZebra Finches Amazing at Unmasking the Bird Behind the Song
      (c) (c) whitehoune / AdobeFrom the Inside Out: How the Brain Forms Sensory Memories
      (c) (c) oatawa / AdobeHealthy Sleep Habits Help Lower Risk of Heart Failure
      LIVING & WELL
      Boy or Girl? It's in the Father's Genes
      Aim to Exceed Weekly Recommended Physical Activity Level to Offset Health Harms of Prolonged Sitting
      Video Games Can Change Your Brain
      advertisement

      Strange & Offbeat
       

      HEALTH & MEDICINE
      Restoring a Rudimentary Form of Vision in the Blind
      Biofriendly Protocells Pump Up Blood Vessels
      Researchers Identify Features That Could Make Someone a Virus Super-Spreader
      MIND & BRAIN
      Restoring a Rudimentary Form of Vision in the Blind
      (c) (c) pelooyen / AdobeZebra Finches Amazing at Unmasking the Bird Behind the Song
      A Malformation Illustrates the Incredible Plasticity of the Brain
      LIVING & WELL
      Key Advance for Printing Circuitry on Wearable Fabrics
      Luminescent Wood Could Light Up Homes of the Future
      Research Lays Groundwork for Ultra-Thin, Energy Efficient Photodetector on Glass
      SD
      • SD
        • Home Page
        • Top Science News
        • Latest News
      • Home
        • Home Page
        • Top Science News
        • Latest News
      • Health
        • View all the latest top news in the health sciences,
          or browse the topics below:
          Health & Medicine
          • Allergy
          • Alternative Medicine
          • Birth Control
          • Cancer
          • Diabetes
          • Diseases
          • Heart Disease
          • HIV and AIDS
          • Obesity
          • Stem Cells
          • ... more topics
          Mind & Brain
          • ADD and ADHD
          • Addiction
          • Alzheimer's
          • Autism
          • Depression
          • Headaches
          • Intelligence
          • Psychology
          • Relationships
          • Schizophrenia
          • ... more topics
          Living Well
          • Parenting
          • Pregnancy
          • Sexual Health
          • Skin Care
          • Men's Health
          • Women's Health
          • Nutrition
          • Diet and Weight Loss
          • Fitness
          • Healthy Aging
          • ... more topics
      • Tech
        • View all the latest top news in the physical sciences & technology,
          or browse the topics below:
          Matter & Energy
          • Aviation
          • Chemistry
          • Electronics
          • Fossil Fuels
          • Nanotechnology
          • Physics
          • Quantum Physics
          • Solar Energy
          • Technology
          • Wind Energy
          • ... more topics
          Space & Time
          • Astronomy
          • Black Holes
          • Dark Matter
          • Extrasolar Planets
          • Mars
          • Moon
          • Solar System
          • Space Telescopes
          • Stars
          • Sun
          • ... more topics
          Computers & Math
          • Artificial Intelligence
          • Communications
          • Computer Science
          • Hacking
          • Mathematics
          • Quantum Computers
          • Robotics
          • Software
          • Video Games
          • Virtual Reality
          • ... more topics
      • Enviro
        • View all the latest top news in the environmental sciences,
          or browse the topics below:
          Plants & Animals
          • Agriculture and Food
          • Animals
          • Biology
          • Biotechnology
          • Endangered Animals
          • Extinction
          • Genetically Modified
          • Microbes and More
          • New Species
          • Zoology
          • ... more topics
          Earth & Climate
          • Climate
          • Earthquakes
          • Environment
          • Geography
          • Geology
          • Global Warming
          • Hurricanes
          • Ozone Holes
          • Pollution
          • Weather
          • ... more topics
          Fossils & Ruins
          • Ancient Civilizations
          • Anthropology
          • Archaeology
          • Dinosaurs
          • Early Humans
          • Early Mammals
          • Evolution
          • Lost Treasures
          • Origin of Life
          • Paleontology
          • ... more topics
      • Society
        • View all the latest top news in the social sciences & education,
          or browse the topics below:
          Science & Society
          • Arts & Culture
          • Consumerism
          • Economics
          • Political Science
          • Privacy Issues
          • Public Health
          • Racial Disparity
          • Religion
          • Sports
          • World Development
          • ... more topics
          Business & Industry
          • Biotechnology & Bioengineering
          • Computers & Internet
          • Energy & Resources
          • Engineering
          • Medical Technology
          • Pharmaceuticals
          • Transportation
          • ... more topics
          Education & Learning
          • Animal Learning & Intelligence
          • Creativity
          • Educational Psychology
          • Educational Technology
          • Infant & Preschool Learning
          • Learning Disorders
          • STEM Education
          • ... more topics
      • Quirky
        • Top News
        • Human Quirks
        • Odd Creatures
        • Bizarre Things
        • Weird World
      Free Subscriptions

      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      • Email Newsletters
      • RSS Feeds
      Follow Us

      Keep up to date with the latest news from ScienceDaily via social networks:

      • Facebook
      • Twitter
      • LinkedIn
      Have Feedback?

      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?

      • Leave Feedback
      • Contact Us
      About This Site  |  Staff  |  Reviews  |  Contribute  |  Advertise  |  Privacy Policy  |  Editorial Policy  |  Terms of Use
      Copyright 2020 ScienceDaily or by other parties, where indicated. All rights controlled by their respective owners.
      Content on this website is for information only. It is not intended to provide medical or other professional advice.
      Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners.
      Financial support for ScienceDaily comes from advertisements and referral programs, where indicated.
      — CCPA: Do Not Sell My Information — — GDPR: Privacy Settings —
      118论坛 118网址之家